Little Endian vs Big Endian?

Endianness is about byte address order. Little endian means the lower significant bytes get the lower addresses. Big endian means the other way around. So it’s about the bytes (8-bit chunks) not nibbles (4-bit chunks). Most computers we use (there are a few exceptions) address bytes at the individual address level.

Taking the -12 example:

Little endian, in memory, would be:

000000: F4
000001: FF

Big endian, in memory, would be:

000000: FF
000001: F4

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