Given the following dataframe:
df = pd.DataFrame([["Australia", 1, 3, 5],
["Bambua", 12, 33, 56],
["Tambua", 14, 34, 58]
], columns=["Country", "Val1", "Val2", "Val10"]
)
It comes down to a simple broadcasting operation:
>>> df["Val1"] - df["Val10"]
0 -4
1 -44
2 -44
dtype: int64