The line UIApplicationMain(argc, argv, nil, NSStringFromClass([AppDelegate class]));
just means that an exception was thrown during the running of your program. This could range from a memory problem, to a simple runtime error. Look in the target debugger console; it will tell you where the error occurred.
Edited due to edited question: I have solved this question before by restoring the iOS simulator to factory defaults (Open “iOS Simulator” Menu in the upper left -> Reset Content and Settings). Then quit the iOS simulator and Xcode, and then restart your computer. This will get rid of the other instance of the process.