@Paul Creasey had the simplest solution as the regex, but here it is as a simple jQuery plugin:
$.fn.digits = function(){
return this.each(function(){
$(this).text( $(this).text().replace(/(\d)(?=(\d\d\d)+(?!\d))/g, "$1,") );
})
}
You could then use it like this:
$("span.numbers").digits();