Check if a process is running or not on Windows?

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You can not rely on lock files in Linux or Windows. I would just bite the bullet and iterate through all the running programs. I really do not believe it will be as “expensive” as you think. psutil is an excellent cross-platform python module cable of enumerating all the running programs on a system.

import psutil    
"someProgram" in (p.name() for p in psutil.process_iter())

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