This is caused by a bug in your Django settings somewhere. Unfortunately, Django’s hiding the bug behind this generic and un-useful error message.
To reveal the true problem, open django/apps/registry.py
and around line 80, replace:
raise RuntimeError("populate() isn't reentrant")
with:
self.app_configs = {}
This will allow Django to continue loading, and reveal the actual error.
I’ve encountered this error for several different causes. Once was because I had a bad import in one of my app’s admin.py.