As proposed in this issue, you could use conditional types to write a XOR type:
type Without<T, U> = { [P in Exclude<keyof T, keyof U>]?: never };
type XOR<T, U> = (T | U) extends object ? (Without<T, U> & U) | (Without<U, T> & T) : T | U;
And now your example works:
interface Person {ethnicity: string;}
interface Pet {breed: string;}
function getOrigin(value: XOR<Person, Pet>) { /* ... */}
getOrigin({}); //Error
getOrigin({ethnicity: 'abc'}); //OK
getOrigin({breed: 'def'}); //OK
getOrigin({ethnicity: 'abc', breed: 'def'});//Error