Drop rows on multiple conditions in pandas dataframe

drop is a method, you are calling it using [], that is why it gives you:

'method' object is not subscriptable

change to () (a normal method call) and it should work:

import pandas as pd

df = pd.DataFrame({"col_1": (0.0, 0.0, 1.0, 1.0, 0.0, 1.0, 1.0),
                   "col_2": (0.0, 0.24, 1.0, 0.0, 0.22, 3.11, 0.0),
                   "col_3": ("Mon", "Tue", "Thu", "Fri", "Mon", "Tue", "Thu")})

df_new = df.drop(df[(df['col_1'] == 1.0) & (df['col_2'] == 0.0)].index)
print(df_new)

Output

   col_1  col_2 col_3
0    0.0   0.00   Mon
1    0.0   0.24   Tue
2    1.0   1.00   Thu
4    0.0   0.22   Mon
5    1.0   3.11   Tue

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