Xcode and the GDB connection is quite temperamental. The device and your Mac can become unsynchronised with each other. My checklist for this sort of thing:
- Restart Xcode.
- Delete the .app from your iOS device, do a Clean then Rebuild.
- Disconnect, reconnect device.
- Restart iOS device (90% of the time it fixes things)
- If all else fails, restart your Mac (unlikely but it did fix an issue once for me).