You are able to run a Python file using HTML using PHP.
Add a PHP file as index.php:
<html>
<head>
<title>Run my Python files</title>
<?PHP
echo shell_exec("python test.py 'parameter1'");
?>
</head>
Passing the parameter to Python
Create a Python file as test.py:
import sys
input=sys.argv[1]
print(input)
Print the parameter passed by PHP.