how I can change the voice synthesizer gender and age in C#?

First, check which voices you have installed by enumerating the GetInstalledVoices method of the SpeechSynthesizer class, and then use SelectVoiceByHints to select one of them:

using (SpeechSynthesizer synthesizer = new SpeechSynthesizer())
{
    // show installed voices
    foreach (var v in synthesizer.GetInstalledVoices().Select(v => v.VoiceInfo))
    {
        Console.WriteLine("Name:{0}, Gender:{1}, Age:{2}",
          v.Description, v.Gender, v.Age);
    }

    // select male senior (if it exists)
    synthesizer.SelectVoiceByHints(VoiceGender.Male, VoiceAge.Senior);

    // select audio device
    synthesizer.SetOutputToDefaultAudioDevice();

    // build and speak a prompt
    PromptBuilder builder = new PromptBuilder();
    builder.AppendText("Found this on Stack Overflow.");
    synthesizer.Speak(builder);
}

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