How to check if a dictionary is empty?

Empty dictionaries evaluate to False in Python:

>>> dct = {}
>>> bool(dct)
False
>>> not dct
True
>>>

Thus, your isEmpty function is unnecessary. All you need to do is:

def onMessage(self, socket, message):
    if not self.users:
        socket.send("Nobody is online, please use REGISTER command" \
                    " in order to register into the server")
    else:
        socket.send("ONLINE " + ' ' .join(self.users.keys()))

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