How to prevent value changed events from firing on form initialization in .NET?

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To make it feel slightly less dirty, if you initialize the controls in the constructor of the form you might be able to use the forms IsHandleCreated property rather than your own bool to check if it should actually validate or not.
I would think that normally you wouldn’t want to validate anything before it’s been shown for the first time and handle isn’t created until it is.

Code Example:

Private Sub myRadioButton_CheckedChanged(sender As Object, e As EventArgs) Handles myRadioButton.CheckedChanged
If myRadioButton.Checked AndAlso myRadioButton.IsHandleCreated Then
    'Do Work
End If
End Sub

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