How to remove multiple items from a list in just one statement?

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In Python, creating a new object e.g. with a list comprehension is often better than modifying an existing one:

item_list = ['item', 5, 'foo', 3.14, True]
item_list = [e for e in item_list if e not in ('item', 5)]

… which is equivalent to:

item_list = ['item', 5, 'foo', 3.14, True]
new_list = []
for e in item_list:
    if e not in ('item', 5):
        new_list.append(e)
item_list = new_list

In case of a big list of filtered out values (here, ('item', 5) is a small set of elements), using a set is faster as the in operation is O(1) time complexity on average. It’s also a good idea to build the iterable you’re removing first, so that you’re not creating it on every iteration of the list comprehension:

unwanted = {'item', 5}
item_list = [e for e in item_list if e not in unwanted]

A bloom filter is also a good solution if memory is not cheap.

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