Splitting image to tiles of MxN pixels (assuming im is numpy.ndarray):
tiles = [im[x:x+M,y:y+N] for x in range(0,im.shape[0],M) for y in range(0,im.shape[1],N)]
In the case you want to split the image to four pieces:
M = im.shape[0]//2
N = im.shape[1]//2
tiles[0] holds the upper left tile