Here is the simplest way:
<select name="ab" onchange="if (this.selectedIndex) doSomething();">
<option value="-1">--</option>
<option value="1">option 1</option>
<option value="2">option 2</option>
<option value="3">option 3</option>
</select>
Works both with mouse selection and keyboard Up/Down keys whes select is focused.