Sure, use a filter.
Here’s the snippet posted on the blog, for future reference – all credit to the author of that blog post:
<filter type="log4net.Filter.LoggerMatchFilter">
<!-- allows this sub-namespace to be logged... -->
<loggerToMatch value="Noisy.Namespace.But.Important" />
</filter>
<filter type="log4net.Filter.LoggerMatchFilter">
<!-- ...but not the rest of it -->
<loggerToMatch value="Noisy.Namespace" />
<acceptOnMatch value="false" />
</filter>