Multiple ggplots of different sizes

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You can use nested arrangeGrob calls like this example:

library(ggplot2)
library(gridExtra)

p <- ggplot(data.frame(x=1, y=1), aes(x,y)) + geom_point()

grid.arrange(
  arrangeGrob(
    p, 
    arrangeGrob(p, p, nrow=2),
    ncol=2 ,widths=c(2,1)),
  arrangeGrob(p, p ,p ,ncol=3, widths=rep(1,3)),
  nrow=2)

Edit:

gl <- lapply(1:9, function(ii) grobTree(rectGrob(),textGrob(ii)))

grid.arrange(
  arrangeGrob(gl[[1]],
              do.call(arrangeGrob, c(gl[2:5], ncol=2)),
              nrow=1,
              widths=3:2),
  do.call(arrangeGrob, c(gl[6:9], nrow=1, list(widths=c(1,1,1,2)))),
nrow=2, heights=c(2,1))

enter image description here

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