mysql_real_escape_string
is not sufficient in all situations but it is definitely very good friend. The better solution is using Prepared Statements
//example from http://php.net/manual/en/pdo.prepared-statements.php
$stmt = $dbh->prepare("INSERT INTO REGISTRY (name, value) VALUES (?, ?)");
$stmt->bindParam(1, $name);
$stmt->bindParam(2, $value);
// insert one row
$name="one";
$value = 1;
$stmt->execute();
Also, not to forget HTMLPurifier that can be used to discard any invalid/suspicious characters.
………..
Edit:
Based on the comments below, I need to post this link (I should have done before sorry for creating confusion)
mysql_real_escape_string() versus Prepared Statements
Quoting:
mysql_real_escape_string() prone to
the same kind of issues affecting
addslashes().
Chris Shiflett (Security Expert)