Before worrying about multiple cores, I would eliminate the linear scan in your ismember function by using a dictionary:
def ismember(a, b):
bind = {}
for i, elt in enumerate(b):
if elt not in bind:
bind[elt] = i
return [bind.get(itm, None) for itm in a] # None can be replaced by any other "not in b" value
Your original implementation requires a full scan of the elements in B for each element in A, making it O(len(A)*len(B)). The above code requires one full scan of B to generate the dict Bset. By using a dict, you effectively make the lookup of each element in B constant for each element of A, making the operation O(len(A)+len(B)). If this is still too slow, then worry about making the above function run on multiple cores.
Edit: I’ve also modified your indexing slightly. Matlab uses 0 because all of its arrays start at index 1. Python/numpy start arrays at 0, so if you’re data set looks like this
A = [2378, 2378, 2378, 2378]
B = [2378, 2379]
and you return 0 for no element, then your results will exclude all elements of A. The above routine returns None for no index instead of 0. Returning -1 is an option, but Python will interpret that to be the last element in the array. None will raise an exception if it’s used as an index into the array. If you’d like different behavior, change the second argument in the Bind.get(item,None) expression to the value you want returned.