The built-in unicodedata
module can do it:
>>> import unicodedata
>>> foo = u'1234567890'
>>> unicodedata.normalize('NFKC', foo)
u'1234567890'
The “NFKC” stands for “Normalization Form KC [Compatibility Decomposition, followed by Canonical Composition]”, and replaces full-width characters by half-width ones, which are Unicode equivalent.
Note that it also normalizes all sorts of other things at the same time, like separate accent marks and Roman numeral symbols.