Thanks to the link from MSK, this is the way I went with which works well:
// Create a mask layer and the frame to determine what will be visible in the view.
CAShapeLayer *maskLayer = [[CAShapeLayer alloc] init];
CGRect maskRect = CGRectMake(0, 0, 50, 100);
// Create a path with the rectangle in it.
CGPathRef path = CGPathCreateWithRect(maskRect, NULL);
// Set the path to the mask layer.
maskLayer.path = path;
// Release the path since it's not covered by ARC.
CGPathRelease(path);
// Set the mask of the view.
viewToMask.layer.mask = maskLayer;