Try either multi-table update syntax
UPDATE config t1 JOIN config t2
ON t1.config_name="name1" AND t2.config_name="name2"
SET t1.config_value="value",
t2.config_value="value2";
Here is a SQLFiddle demo
or conditional update
UPDATE config
SET config_value = CASE config_name
WHEN 'name1' THEN 'value'
WHEN 'name2' THEN 'value2'
ELSE config_value
END
WHERE config_name IN('name1', 'name2');
Here is a SQLFiddle demo