tkinter program compiles with cx_Freeze but program will not launch

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Try to modify you setup.py as follows:

import sys
from cx_Freeze import setup, Executable

import os
PYTHON_INSTALL_DIR = os.path.dirname(sys.executable)
os.environ['TCL_LIBRARY'] = os.path.join(PYTHON_INSTALL_DIR, 'tcl', 'tcl8.6')
os.environ['TK_LIBRARY'] = os.path.join(PYTHON_INSTALL_DIR, 'tcl', 'tk8.6')

include_files = [(os.path.join(PYTHON_INSTALL_DIR, 'DLLs', 'tk86t.dll'), os.path.join('lib', 'tk86t.dll')),
                 (os.path.join(PYTHON_INSTALL_DIR, 'DLLs', 'tcl86t.dll'), os.path.join('lib', 'tcl86t.dll'))]

base = None
if sys.platform == 'win32':
    base="Win32GUI"

executables = [Executable('SimpleTkApp.py', base=base)]

setup(name="simple_Tkinter",
      version='0.1',
      description='Sample cx_Freeze Tkinter script',
      options={'build_exe': {'include_files': include_files}},
      executables=executables)

This should work for cx_Freeze version 5.1.1 (the current version). In this version, the included modules are in a subdirectory lib of the build directory. If you use 5.0.1 or an earlier version, set

include_files = [os.path.join(PYTHON_INSTALL_DIR, 'DLLs', 'tk86t.dll'),
                 os.path.join(PYTHON_INSTALL_DIR, 'DLLs', 'tcl86t.dll')]

instead.

See also Getting “ImportError: DLL load failed: The specified module could not be found” when using cx_Freeze even with tcl86t.dll and tk86t.dll added in and python tkinter exe built with cx_Freeze for windows won’t show GUI

EDIT:

A further problem is that cx_Freeze has a bug with python 3.7 which is not yet corrected. See Cx_freeze crashing Python3.7.0 . You can find there a link to a bug fix which you should apply manually (according to the OP this solved the problem, see comments).

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