In case your CSV is quite large, using INSERTS is very ineffective. You should use a bulk loading mechanisms, which differ from base to base. E.g. in PostgreSQL you should use “COPY FROM” method:
with open(csv_file_path, 'r') as f:
conn = create_engine('postgresql+psycopg2://...').raw_connection()
cursor = conn.cursor()
cmd = 'COPY tbl_name(col1, col2, col3) FROM STDIN WITH (FORMAT CSV, HEADER FALSE)'
cursor.copy_expert(cmd, f)
conn.commit()