That is the type of message you will get when attempting to apply an S4 generic function to an object of a class for which no defined S4 method exists (or at least has been attached to the current R session).
Here’s an example using the raster package (for spatial raster data), which is chock full of S4 functions.
library(raster)
## raster::rotate() is an S4 function with just one method, for "Raster" class objects
isS4(rotate)
# [1] TRUE
showMethods(rotate)
# Function: rotate (package raster)
# x="Raster"
## Lets see what happens when we pass it an object that's *not* of class "Raster"
x <- 1:10
class(x)
# [1] "integer"
rotate(x)
# Error in (function (classes, fdef, mtable) :
# unable to find an inherited method for function ‘rotate’ for signature ‘"integer"’