What is the difference between And and AndAlso in VB.NET?

The And operator evaluates both sides, where AndAlso evaluates the right side if and only if the left side is true.

An example:

If mystring IsNot Nothing And mystring.Contains("Foo") Then
  ' bla bla
End If

The above throws an exception if mystring = Nothing

If mystring IsNot Nothing AndAlso mystring.Contains("Foo") Then
  ' bla bla
End If

This one does not throw an exception.

So if you come from the C# world, you should use AndAlso like you would use &&.

More info here: http://www.panopticoncentral.net/2003/08/18/the-ballad-of-andalso-and-orelse/