There is a work-around mentioned in the changelog for 2.0.0-beta.6 (2016-02-11) (listed under breaking changes):
If you use –target=es5, you will need to add a line somewhere in your application (for example, at the top of the .ts file where you call bootstrap):
///<reference path="node_modules/angular2/typings/browser.d.ts"/>
(Note that if your file is not in the same directory as node_modules, you’ll need to add one or more ../ to the start of that path.)
make sure you have the correct reference path, i needed to add ../ to the start to get this working.