Convert pandas.Series from dtype object to float, and errors to nans

Use pd.to_numeric with errors="coerce"

# Setup
s = pd.Series(['1', '2', '3', '4', '.'])
s

0    1
1    2
2    3
3    4
4    .
dtype: object

pd.to_numeric(s, errors="coerce")

0    1.0
1    2.0
2    3.0
3    4.0
4    NaN
dtype: float64

If you need the NaNs filled in, use Series.fillna.

pd.to_numeric(s, errors="coerce").fillna(0, downcast="infer")

0    1
1    2
2    3
3    4
4    0
dtype: float64

Note, downcast="infer" will attempt to downcast floats to integers where possible. Remove the argument if you don’t want that.

From v0.24+, pandas introduces a Nullable Integer type, which allows
integers to coexist with NaNs. If you have integers in your column,
you can use

pd.__version__
# '0.24.1'

pd.to_numeric(s, errors="coerce").astype('Int32')

0      1
1      2
2      3
3      4
4    NaN
dtype: Int32

There are other options to choose from as well, read the docs for more.

---

Extension for DataFrames

If you need to extend this to DataFrames, you will need to apply it to each row. You can do this using DataFrame.apply.

# Setup.
np.random.seed(0)
df = pd.DataFrame({
    'A' : np.random.choice(10, 5), 
    'C' : np.random.choice(10, 5), 
    'B' : ['1', '###', '...', 50, '234'], 
    'D' : ['23', '1', '...', '268', '$$']}
)[list('ABCD')]
df

   A    B  C    D
0  5    1  9   23
1  0  ###  3    1
2  3  ...  5  ...
3  3   50  2  268
4  7  234  4   $$

df.dtypes

A     int64
B    object
C     int64
D    object
dtype: object

df2 = df.apply(pd.to_numeric, errors="coerce")
df2

   A      B  C      D
0  5    1.0  9   23.0
1  0    NaN  3    1.0
2  3    NaN  5    NaN
3  3   50.0  2  268.0
4  7  234.0  4    NaN

df2.dtypes

A      int64
B    float64
C      int64
D    float64
dtype: object

You can also do this with DataFrame.transform; although my tests indicate this is marginally slower:

df.transform(pd.to_numeric, errors="coerce")

   A      B  C      D
0  5    1.0  9   23.0
1  0    NaN  3    1.0
2  3    NaN  5    NaN
3  3   50.0  2  268.0
4  7  234.0  4    NaN

If you have many columns (numeric; non-numeric), you can make this a little more performant by applying pd.to_numeric on the non-numeric columns only.

df.dtypes.eq(object)

A    False
B     True
C    False
D     True
dtype: bool

cols = df.columns[df.dtypes.eq(object)]
# Actually, `cols` can be any list of columns you need to convert.
cols
# Index(['B', 'D'], dtype="object")

df[cols] = df[cols].apply(pd.to_numeric, errors="coerce")
# Alternatively,
# for c in cols:
#     df[c] = pd.to_numeric(df[c], errors="coerce")

df

   A      B  C      D
0  5    1.0  9   23.0
1  0    NaN  3    1.0
2  3    NaN  5    NaN
3  3   50.0  2  268.0
4  7  234.0  4    NaN

Applying pd.to_numeric along the columns (i.e., axis=0, the default) should be slightly faster for long DataFrames.