Pandas DataFrames with NaNs equality comparison

You can use assert_frame_equals with check_names=False (so as not to check the index/columns names), which will raise if they are not equal:

In [11]: from pandas.testing import assert_frame_equal

In [12]: assert_frame_equal(df, expected, check_names=False)

You can wrap this in a function with something like:

try:
    assert_frame_equal(df, expected, check_names=False)
    return True
except AssertionError:
    return False

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In more recent pandas this functionality has been added as .equals:

df.equals(expected)