To get the exact column in a worksheet, use this code.
Option Explicit
Sub Sample()
Dim ws As Worksheet
Dim LastCol As Long
Set ws = Sheets("Sheet1")
'~~> This check is required else .FIND will give you error on an empty sheet
If Application.WorksheetFunction.CountA(ws.Cells) = 0 Then
LastCol = 1
Else
LastCol = ws.Cells.Find(What:="*", _
After:=ws.Range("A1"), _
Lookat:=xlPart, _
LookIn:=xlFormulas, _
SearchOrder:=xlByColumns, _
SearchDirection:=xlPrevious, _
MatchCase:=False).Column
End If
Debug.Print LastCol
End Sub
EDIT: This is courtesy @brettdj. You can also use the range object to find the last column
Option Explicit
Sub Sample()
Dim ws As Worksheet
Dim LastCol As Long
Dim rng As Range
Set ws = Sheets("Sheet1")
Set rng = ws.Cells.Find(What:="*", _
After:=ws.Range("A1"), _
Lookat:=xlPart, _
LookIn:=xlFormulas, _
SearchOrder:=xlByColumns, _
SearchDirection:=xlPrevious, _
MatchCase:=False)
If rng Is Nothing Then
LastCol = 1
Else
LastCol = rng.Column
End If
Debug.Print LastCol
End Sub
To get the last column of a particular row, say row 1 use this
Debug.Print ws.Cells(1, ws.Columns.Count).End(xlToLeft).Column
Where ws is your relevant worksheet.
Similarly for Row see this.