As per https://stackoverflow.com/a/38231651/454773, you can use .apply(pd.Series)
to map the dict containing column onto new columns and then concatenate these new columns back into the original dataframe minus the original dict containing column:
dw=pd.DataFrame( [[20, 30, {"ab":"1", "we":"2", "as":"3"},"String"]],
columns=['ColA', 'ColB', 'ColC', 'ColdD'])
pd.concat([dw.drop(['ColC'], axis=1), dw['ColC'].apply(pd.Series)], axis=1)
Returns:
ColA ColB ColdD ab as we
20 30 String 1 3 2