disable or lock mouse and keyboard in Python?

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I haven’t tested (actually I’ve tested the mouse part, and it annoyingly works) but something like this using pyhook would do what you want:

import pythoncom, pyHook 

def uMad(event):
    return False

hm = pyHook.HookManager()
hm.MouseAll = uMad
hm.KeyAll = uMad
hm.HookMouse()
hm.HookKeyboard()
pythoncom.PumpMessages()

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