Pandas – dataframe groupby – how to get sum of multiple columns

By using apply

df.groupby(['col1', 'col2'])["col3", "col4"].apply(lambda x : x.astype(int).sum())
Out[1257]: 
           col3  col4
col1 col2            
a    c        2     4
     d        1     2
b    d        1     2
     e        2     4

If you want to agg

df.groupby(['col1', 'col2']).agg({'col3':'sum','col4':'sum'})