Disabling particular Items in a Combobox

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Try this… Does it serve your purpose:

I assume you have a combobox called ComboBox1 and you want to disable the second item i.e. an item with index 1.

Set the DrawMode property of the combobox to OwnerDrawFixed then handle these two events as shown below:

Font myFont = new Font("Aerial", 10, FontStyle.Regular);

private void comboBox1_DrawItem(object sender, DrawItemEventArgs e)
{        
    if (e.Index == 1) //We are disabling item based on Index, you can have your logic here
    {
        e.Graphics.DrawString(comboBox1.Items[e.Index].ToString(), myFont, Brushes.LightGray, e.Bounds);
    }
    else
    {
        e.DrawBackground();
        e.Graphics.DrawString(comboBox1.Items[e.Index].ToString(), myFont, Brushes.Black, e.Bounds);
        e.DrawFocusRectangle();
    }
} 

void comboBox1_SelectedIndexChanged(object sender, EventArgs e)
{
    if (comboBox1.SelectedIndex == 1)
        comboBox1.SelectedIndex = -1;
}

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