Efficient way to remove ALL whitespace from String?

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This is fastest way I know of, even though you said you didn’t want to use regular expressions:

Regex.Replace(XML, @"\s+", "");

Crediting @hypehuman in the comments, if you plan to do this more than once, create and store a Regex instance. This will save the overhead of constructing it every time, which is more expensive than you might think.

private static readonly Regex sWhitespace = new Regex(@"\s+");
public static string ReplaceWhitespace(string input, string replacement) 
{
    return sWhitespace.Replace(input, replacement);
}

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