pandas >= 0.25

Assuming all columns have the same number of lists, you can call Series.explode on each column.

df.set_index(['A']).apply(pd.Series.explode).reset_index()

    A   B   C   D   E
0  x1  v1  c1  d1  e1
1  x1  v2  c2  d2  e2
2  x2  v3  c3  d3  e3
3  x2  v4  c4  d4  e4
4  x3  v5  c5  d5  e5
5  x3  v6  c6  d6  e6
6  x4  v7  c7  d7  e7
7  x4  v8  c8  d8  e8

The idea is to set as the index all columns that must NOT be exploded first, then reset the index after.

---

It’s also faster.

%timeit df.set_index(['A']).apply(pd.Series.explode).reset_index()
%%timeit
(df.set_index('A')
   .apply(lambda x: x.apply(pd.Series).stack())
   .reset_index()
   .drop('level_1', 1))


2.22 ms ± 98.6 µs per loop (mean ± std. dev. of 7 runs, 100 loops each)
9.14 ms ± 329 µs per loop (mean ± std. dev. of 7 runs, 100 loops each)