How to do sed like text replace with python?

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You can do that like this:

with open("/etc/apt/sources.list", "r") as sources:
    lines = sources.readlines()
with open("/etc/apt/sources.list", "w") as sources:
    for line in lines:
        sources.write(re.sub(r'^# deb', 'deb', line))

The with statement ensures that the file is closed correctly, and re-opening the file in "w" mode empties the file before you write to it. re.sub(pattern, replace, string) is the equivalent of s/pattern/replace/ in sed/perl.

Edit: fixed syntax in example

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