IIUC you can format the xticks and set these:
In[60]:
#generate some psuedo data
df = pd.DataFrame({'num':[50000, 75000, 100000, 125000], 'Rent/Sqft':np.random.randn(4), 'Region':list('abcd')})
df
Out[60]:
num Rent/Sqft Region
0 50000 0.109196 a
1 75000 0.566553 b
2 100000 -0.274064 c
3 125000 -0.636492 d
In[61]:
import matplotlib.pyplot as plt
import matplotlib.ticker as ticker
import seaborn as sns
import pandas as pd
sns.set(style="darkgrid")
fig, ax = plt.subplots(figsize=(8, 5))
palette = sns.color_palette("bright", 4)
g = sns.scatterplot(ax=ax, x="num", y="Rent/Sqft", hue="Region", marker="o", data=df, s=100, palette= palette)
g.legend(bbox_to_anchor=(1, 1), ncol=1)
g.set(xlim = (50000,250000))
xlabels = ['{:,.2f}'.format(x) + 'K' for x in g.get_xticks()/1000]
g.set_xticklabels(xlabels)
Out[61]:
The key bit here is this line:
xlabels = ['{:,.2f}'.format(x) + 'K' for x in g.get_xticks()/1000]
g.set_xticklabels(xlabels)
So this divides all the ticks by 1000 and then formats them and sets the xtick labels
UPDATE
Thanks to @ScottBoston who has suggested a better method:
ax.xaxis.set_major_formatter(ticker.FuncFormatter(lambda x, pos: '{:,.2f}'.format(x/1000) + 'K'))
see the docs