How to replace multiple strings in a file using PowerShell

One option is to chain the -replace operations together. The ` at the end of each line escapes the newline, causing PowerShell to continue parsing the expression on the next line:

$original_file="path\filename.abc"
$destination_file="path\filename.abc.new"
(Get-Content $original_file) | Foreach-Object {
    $_ -replace 'something1', 'something1aa' `
       -replace 'something2', 'something2bb' `
       -replace 'something3', 'something3cc' `
       -replace 'something4', 'something4dd' `
       -replace 'something5', 'something5dsf' `
       -replace 'something6', 'something6dfsfds'
    } | Set-Content $destination_file

Another option would be to assign an intermediate variable:

$x = $_ -replace 'something1', 'something1aa'
$x = $x -replace 'something2', 'something2bb'
...
$x

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