With pandas 0.18 the resample API changed (see the docs).
So for pandas >= 0.18 the answer is:
In [31]: frame.resample('1H').agg({'radiation': np.sum, 'tamb': np.mean})
Out[31]:
tamb radiation
2012-04-05 08:00:00 5.161235 279.507182
2012-04-05 09:00:00 4.968145 290.941073
2012-04-05 10:00:00 4.478531 317.678285
2012-04-05 11:00:00 4.706206 335.258633
2012-04-05 12:00:00 2.457873 8.655838
Old Answer:
I am answering my question to reflect the time series related changes in pandas >= 0.8
(all other answers are outdated).
Using pandas >= 0.8 the answer is:
In [30]: frame.resample('1H', how={'radiation': np.sum, 'tamb': np.mean})
Out[30]:
tamb radiation
2012-04-05 08:00:00 5.161235 279.507182
2012-04-05 09:00:00 4.968145 290.941073
2012-04-05 10:00:00 4.478531 317.678285
2012-04-05 11:00:00 4.706206 335.258633
2012-04-05 12:00:00 2.457873 8.655838