IsAssignableFrom, IsInstanceOfType and the is keyword, what is the difference?

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You use whatever you have the information for.

If you have an instance and a static type you want to check against, use is.

If you don’t have the static type, you just have a Type object, but you have an instance you want to check, use IsInstanceOfType.

If you don’t have an instance and you just want to check the compatibility between a theoretical instance of a Type and another Type, use IsAssignableFrom.

But really is seems like you are just re-implementing the as operator (except that yours would also work for non-nullable value types, which is usually not a big limitation).

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