Media Query grouping instead of multiple scattered media queries that match

First, your solution given in the question certainly has some usefulness to it.

One thing I thought, however, was that it would be nice to define all the media query variables “near” one another (your solution would have them under each media query call). So I propose the following as an alternative solution. It also has drawbacks, one being perhaps a bit more coding up front.

LESS Code

//define our break points as variables
@mediaBreak1: 800px;
@mediaBreak2: 1024px;
@mediaBreak3: 1280px;

//this mixin builds the entire media query based on the break number
.buildMediaQuery(@min) {
    @media only screen and (min-width: @min) { 

        //define a variable output mixin for a class included in the query
        .myClass1(@color) {
            .myClass1 {
               color: @color;
            }
        }

        //define a builder guarded mixin for each break point of the query
        //in these is where we change the variable for the media break (here, color)
        .buildMyClass1() when (@min = @mediaBreak1) {
           .myClass1(red);
        }
        .buildMyClass1() when (@min = @mediaBreak2) {
           .myClass1(green);
        }
        .buildMyClass1() when (@min = @mediaBreak3) {
           .myClass1(blue);
        }

        //call the builder mixin
        .buildMyClass1();

        //define a variable output mixin for a nested selector included in the query
        .mySelector1(@fontSize) {
           section {
              width: (@min - 40);
              margin: 0 auto;
              a {
                font-size: @fontSize;
              }
           } 
        }

        //Again, define a builder guarded mixin for each break point of the query
        //in these is where we change the variable for the media break (here, font-size)
        .buildMySelector1() when (@min = @mediaBreak1) {
           .mySelector1(10px);
        }
        .buildMySelector1() when (@min = @mediaBreak2) {
           .mySelector1(12px);
        }
        .buildMySelector1() when (@min = @mediaBreak3) {
           .mySelector1(14px);
        }

        //call the builder mixin
        .buildMySelector1();

        //ect., ect., etc. for as many parts needed in the media queries.
    }
}

//call our code to build the queries
.buildMediaQuery(@mediaBreak1);
.buildMediaQuery(@mediaBreak2);
.buildMediaQuery(@mediaBreak3);

CSS Output

@media only screen and (min-width: 800px) {
  .myClass1 {
    color: #ff0000;
  }
  section {
    width: 760px;
    margin: 0 auto;
  }
  section a {
    font-size: 10px;
  }
}
@media only screen and (min-width: 1024px) {
  .myClass1 {
    color: #008000;
  }
  section {
    width: 984px;
    margin: 0 auto;
  }
  section a {
    font-size: 12px;
  }
}
@media only screen and (min-width: 1280px) {
  .myClass1 {
    color: #0000ff;
  }
  section {
    width: 1240px;
    margin: 0 auto;
  }
  section a {
    font-size: 14px;
  }
}