You can typecast to int using astype(int)
and divide it by 10**9
to get the number of seconds to the unix epoch start.
import pandas as pd
df = pd.DataFrame({'time': [pd.to_datetime('2019-01-15 13:25:43')]})
df_unix_sec = pd.to_datetime(df['time']).astype(int)/ 10**9
print(df_unix_sec)