Since version 1.9.2 (I think) you can actually pass the parameters as a hash to the URI::encode_www_form method like this:
require 'uri'
uri = URI.parse('http://www.example.com/search.cgi')
params = { :q => "ruby", :max => "50" }
# Add params to URI
uri.query = URI.encode_www_form( params )
and then fetch the result, depending on your preference
require 'open-uri'
puts uri.open.read
or
require 'net/http'
puts Net::HTTP.get(uri)