PowerShell script to check an application that’s locking a file?

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You can do this with the SysInternals tool handle.exe. Try something like this:

PS> $handleOut = handle
PS> foreach ($line in $handleOut) { 
        if ($line -match '\S+\spid:') {
            $exe = $line
        } 
        elseif ($line -match 'C:\\Windows\\Fonts\\segoeui\.ttf')  { 
            "$exe - $line"
        }
     }
MSASCui.exe pid: 5608 ACME\hillr -   568: File  (---)   C:\Windows\Fonts\segoeui.ttf
...

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