Remove duplicate rows from Pandas dataframe where only some columns have the same value

Use drop_duplicates with parameter subset, for keeping only last duplicated rows add keep='last':

df1 = df.drop_duplicates(subset=['A','B'])
#same as
#df1 = df.drop_duplicates(subset=['A','B'], keep='first')
print (df1)
   A  B  C
0  1  2  x
2  3  4  z
3  3  5  x

---

df2 = df.drop_duplicates(subset=['A','B'], keep='last')
print (df2)
   A  B  C
1  1  2  y
2  3  4  z
3  3  5  x