lines_per_file = 300
smallfile = None
with open('really_big_file.txt') as bigfile:
for lineno, line in enumerate(bigfile):
if lineno % lines_per_file == 0:
if smallfile:
smallfile.close()
small_filename="small_file_{}.txt".format(lineno + lines_per_file)
smallfile = open(small_filename, "w")
smallfile.write(line)
if smallfile:
smallfile.close()