From the answer to another question:
public static bool IsAssignableToGenericType(Type givenType, Type genericType)
{
var interfaceTypes = givenType.GetInterfaces();
foreach (var it in interfaceTypes)
{
if (it.IsGenericType && it.GetGenericTypeDefinition() == genericType)
return true;
}
if (givenType.IsGenericType && givenType.GetGenericTypeDefinition() == genericType)
return true;
Type baseType = givenType.BaseType;
if (baseType == null) return false;
return IsAssignableToGenericType(baseType, genericType);
}