.container_12 .grid_6,
.container_16 .grid_8 {
width: 460px;
}
That says “make all .grid_6’s within .container_12’s and all .grid_8’s within .container_16’s 460 pixels wide.” So both of the following will render the same:
<div class="container_12">
<div class="grid_6">460px Wide</div>
</div>
<div class="container_16">
<div class="grid_8">460px Wide</div>
</div>
As for the commas, it’s applying one rule to multiple classes, like this.
.blueCheese, .blueBike {
color:blue;
}
It’s functionally equivalent to:
.blueCheese { color:blue }
.blueBike { color:blue }
But cuts down on verbosity.